Dr. Marty Makary has resigned as head of the U.S. Food and Drug Administration (the federal agency responsible for regulating medicines, food, and medical devices) after roughly a year in the role marked by staff upheaval, political interference, and pressure from Republican interest groups. A surgeon who rose to prominence as a Fox News commentator critical of COVID-19 restrictions, Makary struggled to manage the agency amid mass layoffs, a revolving door of senior leadership, and disputes over vaccine policy, abortion pill reviews, and e-cigarette approvals. Kyle Diamantas, the agency's foods chief and an attorney with ties to Donald Trump Jr., is expected to serve as acting commissioner while a permanent replacement undergoes Senate confirmation.