Novak Djokovic's pursuit of a record 25th Grand Slam title has suffered a major setback after the 39-year-old Serbian was eliminated in the third round of the French Open by Brazilian teenager Joao Fonseca on Friday. The 19-year-old came back from two sets down to win 4–6, 4–6, 6–3, 7–5, 7–5 in an epic match lasting four hours and 53 minutes — Djokovic's longest ever at Roland Garros, the Paris clay-court tournament also known as the French Open.

Fonseca, ranked 30th in the world and widely regarded as one of the sport's most exciting young talents, became the first teenager to beat Djokovic in a Grand Slam match. He dedicated the victory to his mother, who was watching from the stands on her birthday. The young Brazilian had been two sets down in his previous match as well, making it two consecutive comebacks from that deficit. In the deciding fifth set, he recovered from 1–3 down, broke Djokovic to lead 6–5, and then sealed the win with three consecutive aces.